Detalhe da pesquisa
1.
Accurate de novo design of membrane-traversing macrocycles.
Cell
; 185(19): 3520-3532.e26, 2022 09 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-36041435
2.
Elicitation of broadly protective sarbecovirus immunity by receptor-binding domain nanoparticle vaccines.
Cell
; 184(21): 5432-5447.e16, 2021 10 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-34619077
3.
An Early Treatment With BKI-1748 Exhibits Full Protection Against Abortion and Congenital Infection in Sheep Experimentally Infected With Toxoplasma gondii.
J Infect Dis
; 229(2): 558-566, 2024 Feb 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-37889572
4.
Molecular Targets of the 5-Amido-Carboxamide Bumped Kinase Inhibitor BKI-1748 in Cryptosporidium parvum and HCT-8 Host Cells.
Int J Mol Sci
; 25(5)2024 Feb 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-38473953
5.
Rapid Epidemic Expansion of Chikungunya Virus East/Central/South African Lineage, Paraguay.
Emerg Infect Dis
; 29(9): 1859-1863, 2023 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-37488810
6.
Comparison of Toxicities among Different Bumped Kinase Inhibitor Analogs for Treatment of Cryptosporidiosis.
Antimicrob Agents Chemother
; 67(4): e0142522, 2023 04 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-36920244
7.
Appraisal of Fungus-Derived Xanthoquinodins as Broad-Spectrum Anti-Infectives Targeting Phylogenetically Diverse Human Pathogens.
J Nat Prod
; 86(6): 1596-1605, 2023 06 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-37276438
8.
Single and combination treatment of Toxoplasma gondii infections with a bumped kinase inhibitor and artemisone in vitro and with artemiside in experimentally infected mice.
Exp Parasitol
; 255: 108655, 2023 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-37981259
9.
Pharmacokinetics and Pharmacodynamics of Clofazimine for Treatment of Cryptosporidiosis.
Antimicrob Agents Chemother
; 66(1): e0156021, 2022 01 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-34748385
10.
Common Molecular Targets of a Quinolone Based Bumped Kinase Inhibitor in Neospora caninum and Danio rerio.
Int J Mol Sci
; 23(4)2022 Feb 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-35216497
11.
Chemoprophylaxis Vaccination: Phase I Study to Explore Stage-specific Immunity to Plasmodium falciparum in US Adults.
Clin Infect Dis
; 71(6): 1481-1490, 2020 09 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-31621832
12.
Taming the Boys for Global Good: Contraceptive Strategy to Stop Malaria Transmission.
Molecules
; 25(12)2020 Jun 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-32560085
13.
P-Glycoprotein-Mediated Efflux Reduces the In Vivo Efficacy of a Therapeutic Targeting the Gastrointestinal Parasite Cryptosporidium.
J Infect Dis
; 220(7): 1188-1198, 2019 08 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-31180118
14.
Pharmacokinetics and In Vivo Efficacy of Pyrazolopyrimidine, Pyrrolopyrimidine, and 5-Aminopyrazole-4-Carboxamide Bumped Kinase Inhibitors against Toxoplasmosis.
J Infect Dis
; 219(9): 1464-1473, 2019 04 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-30423128
15.
Enzymatic and Structural Characterization of the Naegleria fowleri Glucokinase.
Antimicrob Agents Chemother
; 63(5)2019 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-30783001
16.
Treatment with Bumped Kinase Inhibitor 1294 Is Safe and Leads to Significant Protection against Abortion and Vertical Transmission in Sheep Experimentally Infected with Toxoplasma gondii during Pregnancy.
Antimicrob Agents Chemother
; 63(7)2019 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-31061151
17.
Optimization of Methionyl tRNA-Synthetase Inhibitors for Treatment of Cryptosporidium Infection.
Antimicrob Agents Chemother
; 63(4)2019 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-30745384
18.
Susceptibility Testing of Medically Important Parasites.
Clin Microbiol Rev
; 30(3): 647-669, 2017 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-28446445
19.
Therapeutic Efficacy of Bumped Kinase Inhibitor 1369 in a Pig Model of Acute Diarrhea Caused by Cryptosporidium hominis.
Antimicrob Agents Chemother
; 62(7)2018 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-29661877
20.
Toxoplasma Calcium-Dependent Protein Kinase 1 Inhibitors: Probing Activity and Resistance Using Cellular Thermal Shift Assays.
Antimicrob Agents Chemother
; 62(6)2018 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-29555627